Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation

Study Purpose

The aim of the study is to investigate pulmonary hemodynamics at rest and during exercise in patients before and after kidney transplantation.

Recruitment Criteria

Accepts Healthy Volunteers Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms	No
Study Type An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies.	Observational
Eligible Ages	18 Years and Over
Gender	All

More Inclusion & Exclusion Criteria

Inclusion Criteria:

- Age: ≥ 18 years.

- patients listed for first kidney transplantation at the Clinical Division of Nephrology.

Exclusion Criteria:

- Age < 18 years.

- combined organ transplantations (heart-kidney, pancreas-kidney etc.) - patients with prior kidney transplantation.

- high calcium score on cardiac-CT (> 160 Agatston Score)

Trial Details

Trial ID: This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.	NCT04842591
Phase Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.
Lead Sponsor The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.	Medical University of Graz
Principal Investigator The person who is responsible for the scientific and technical direction of the entire clinical study.	Gabor Kovacs, MD, PhD
Principal Investigator Affiliation	Medical University of Graz, Department of Internal Medicine, Division of Pulmonology
Agency Class Category of organization(s) involved as sponsor (and collaborator) supporting the trial.	Other, Industry
Overall Status	Recruiting
Countries	Austria
Conditions The disease, disorder, syndrome, illness, or injury that is being studied.	Pulmonary Hypertension, Kidney Transplantation, Haemodialysis

Arms & Interventions

Arms

: kidney transplant candidates

Patients listed for first kidney transplantation

Interventions

Diagnostic Test: - exercise echocardiography

All patients will undergo exercise echocardiography during a symptom-limited cardiopulmonary exercise test.

Contact a Trial Team

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