Pulmonary hypertension (PH) is defined as a pulmonary arterial mean pressure (meanPAP) ≥ 25
mmHg measured in the right heart catheterization.
There are different forms of PH defined in the classification of Dana Point 2008.
PH is diagnosed with right heart catheterization but there are other non invasive methods
which can be used for screening like the echocardiography, stress echocardiography and cardio
pulmonary exercise testing. In the diagnosis process and in the follow up of PH patients
biomarkers like NTproBNP are helpful. There are no specific biomarkers for the disease which
can make the diagnosis process easier and predict prognosis.
The systematic data collection in a data base provides better information about patients in
daily routine and clinical studies as well as in the design of new studies.
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.
An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.
Searching Both is inclusive of interventional and observational studies.
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.
Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.
Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.
Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.
The person who is responsible for the scientific and technical direction of the entire clinical study.
Category of organization(s) involved as sponsor (and collaborator) supporting the trial.
The disease, disorder, syndrome, illness, or injury that is being studied.
In this study the investigators want to collect clinical data of PH patients and controls in
a database as well as blood samples in a biobank. The combination of anamnestic and clinical
data and biomarkers should provide a better characterization of our patients and should
improve the analysis of the disease development of different PH forms and therapeutic
After given informed consent patients' data are entered in a database at different time
points. The database includes parameter of several invasive and non-invasive investigations
like right heart catheterization (RHC), echocardiography, ECG, pulmonary function tests,
cardiorespiratory exercise testing, 6-minute walk test, computed tomography, MRI,
polysomnography, blood gas analysis and laboratory data as well as demographic data of the
The blood samples are taken during routine punctuation and are stored in our biobank.
: Patients of our outpatient clinic
Patients who have an investigation in our outpatient clinic for pulmonary hypertension like a echocardiography, a right heart catheterization or a cardio pulmonary exercise testing
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Medical University of Graz
Graz, , 8010
Horst Olschewski, MD