Clinical Trial Finder

Inclusion Criteria:

• - Written informed consent to participate in the study obtained from the patient, according to local regulations, prior to initiation of any study mandated procedure.

• - Male or female, ≥ 18 years of age at the time of screening.

• - Patient with known pulmonary hypertension (PH) due to left heart disease (WHO Group II) diagnosed as either HFpEF or HFrEF at chronic state receiving stable guideline directed medical therapy.

• - Combined post-capillary and precapillary pulmonary hypertension diagnosis confirmed by hemodynamic evaluation performed prior to screening or during baseline (Eligibility II visit) procedure.

• - Patient with a current diagnosis of NYHA functional class II/III.

• - Patient with eGFR levels of ≥ 30 ml/min/1.73m2or serum creatinine levels of ˂ 150μmol/l.

Exclusion Criteria:

• - Pregnant women or women planning a pregnancy within 12 months of study enrolment.

• - Patient with significant co-morbid condition(s) which, at the discretion of the PI, are deemed to prohibit study entry.

• - Patient with life expectancy of less than a year.

• - Concurrent enrollment in another device or drug trial except for observational studies (unless specifically approved by the sponsor) - Patient with pulmonary artery anatomy that precludes treatment.

• - Patient with moderate to severe pulmonary artery stenosis.

• - Patient with any pulmonary artery aneurysm.

• - Patient who has experienced a myocardial infarction, unstable angina pectoris, or a cerebrovascular accident in the previous 6 months.

• - Patient experiencing a current episode of acute decompensated heart failure.

• - Patient who has cardiac pacemakers/ICD/CRT-D that were implanted fewer than three months prior to enrolment.

Patient who has implantable Cardiomems device, neurostimulators or drug infusion devices, regardless of implant date.