A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

Study Purpose

Study ROR-PH-303, ADVANCE EXTENSION, is an open-label extension (OLE) study for participants with WHO Group 1 PAH who have participated in another Phase 2 or Phase 3 study of ralinepag.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

1. Evidence of a personally signed and dated informed consent form indicating that the subject has been informed of all pertinent aspects of the study prior to initiation of any study-related procedures. 2. Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures. 3. Completed the protocol-defined Study Drug Termination Visit or End of Study Visit procedures in the preceding ralinepag study. 4. Both male and female subjects agree to use a medically acceptable method of contraception throughout the entire study period from informed consent through the 30 day Follow-up Visit, if the possibility of conception exists. Eligible male and female subjects must also agree not to participate in a conception process (i.e., actively attempt to become pregnant or to impregnate, sperm donation, in vitro fertilization) during the study and for 30 days after the last dose of ralinepag.

Exclusion Criteria:

1. Subjects who prematurely discontinued investigational medicinal product (IMP) due to a drug-related AE/SAE or tolerability issue in the preceding ralinepag study in which they were enrolled, or subjects who did not complete all protocol defined study procedures at a Study Drug Termination Visit or End of Study Visit in the preceding ralinepag study. 2. Subjects who withdrew consent during participation in another ralinepag study. 3. Female subjects who wish to become pregnant or who have a positive pregnancy test on Day 1 (OLE Entry Visit), or are lactating or breastfeeding. 4. Subjects who have undergone lung or heart/lung transplant or the initiation of long-term parenteral or inhaled therapy with a prostacyclin during the time since participation in their original ralinepag study. 5. Subjects who had an emergency unblinding procedure in a prior Phase 2 or 3 study.

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT03683186
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

United Therapeutics
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

N/A
Principal Investigator Affiliation N/A
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Industry
Overall Status Enrolling by invitation
Countries Argentina, Australia, Austria, Belgium, Brazil, Bulgaria, Canada, Chile, China, Croatia, Czechia, Denmark, France, Germany, Greece, Hungary, Israel, Italy, Korea, Republic of, Mexico, Netherlands, Poland, Portugal, Romania, Serbia, Singapore, Spain, Sweden, Taiwan, Turkey, Ukraine, United Kingdom, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension, Connective Tissue Diseases, Familial Primary Pulmonary Hypertension, Vascular Diseases, Cardiovascular Diseases, Hypertension, Pulmonary, Lung Diseases, Respiratory Tract Disease
Additional Details

Study ROR-PH-303 is a multicenter, open-label extension (OLE) study for subjects with WHO Group 1 PAH who have participated in another Phase 2 or Phase 3 study of ralinepag and who qualify for entry based upon participation in the prior study. Subjects who discontinue participation in a prior study due to safety issues related to study medication or who fail to complete study procedures will not be eligible to enter Study ROR-PH-303. Subjects who meet all OLE entry criteria will be enrolled and will receive ralinepag in addition to their pre-existing PAH disease-specific background therapy. For subjects who are enrolled from an ongoing double-blind Phase 2 or Phase 3 ralinepag study, a 16-week blinded Dose Titration Period will be completed following enrollment into the OLE. Subjects previously on ralinepag will continue on the same dose during the Dose Titration Period as received in the original study and will also initiate placebo treatment in the OLE. Subjects who are enrolled from a non-blinded study or another OLE will not participate in the blinded Dose Titration Period in Study ROR-PH-303 but will be enrolled directly into the Treatment Period and continue on the dose of ralinepag received in the original study. All subjects will receive ralinepag in the OLE study until premature discontinuation of ralinepag due to an AE/serious adverse event (SAE) or other reason, marketing approval of ralinepag is granted in the region in which the study is conducted, or the study is discontinued by the Sponsor.

Arms & Interventions

Arms

Experimental: Ralinepag

Ralinepag once daily extended-release tablets (oral) 50, 250, and 400 mcg titrated to the highest tolerated dose.

Interventions

Drug: - Ralinepag

Active

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

University of Alabama at Birmingham, Birmingham, Alabama

Status

Address

University of Alabama at Birmingham

Birmingham, Alabama, 35294

University of Arizona, Tucson, Arizona

Status

Address

University of Arizona

Tucson, Arizona, 85724

UCSD Health Sciences, La Jolla, California

Status

Address

UCSD Health Sciences

La Jolla, California, 92037

Loma Linda University Medical Center, Loma Linda, California

Status

Address

Loma Linda University Medical Center

Loma Linda, California, 92354

Ronald Reagan UCLA Medical Center, Los Angeles, California

Status

Address

Ronald Reagan UCLA Medical Center

Los Angeles, California, 90024

Los Angeles, California

Status

Address

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027

Keck Hospital of USC, Los Angeles, California

Status

Address

Keck Hospital of USC

Los Angeles, California, 90033

Cedars-Sinai Medical Center, Los Angeles, California

Status

Address

Cedars-Sinai Medical Center

Los Angeles, California, 90048

VA Greater Los Angeles Healthcare System, Los Angeles, California

Status

Address

VA Greater Los Angeles Healthcare System

Los Angeles, California, 90073

University of California, Irvine, Orange, California

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Address

University of California, Irvine

Orange, California, 92868

Sacramento, California

Status

Address

University of California Davis Medical Center

Sacramento, California, 95817

Santa Barbara Cottage Hospital, Santa Barbara, California

Status

Address

Santa Barbara Cottage Hospital

Santa Barbara, California, 93105

Stanford University Medical Center, Stanford, California

Status

Address

Stanford University Medical Center

Stanford, California, 94305

University of Colorado Hospital, Aurora, Colorado

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Address

University of Colorado Hospital

Aurora, Colorado, 80045

National Jewish Health, Denver, Colorado

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Address

National Jewish Health

Denver, Colorado, 80206

University of Florida, Gainesville, Florida

Status

Address

University of Florida

Gainesville, Florida, 32610

University of Miami, Miami, Florida

Status

Address

University of Miami

Miami, Florida, 33136

Central Florida Pulmonary Group, Orlando, Florida

Status

Address

Central Florida Pulmonary Group

Orlando, Florida, 32803

Orlando, Florida

Status

Address

Investigational Drug Services, AdventHealth Orlando (Drug Shipment Address)

Orlando, Florida, 32804

Cleveland Clinic Florida, Weston, Florida

Status

Address

Cleveland Clinic Florida

Weston, Florida, 33331

Emory University Hospital, Atlanta, Georgia

Status

Address

Emory University Hospital

Atlanta, Georgia, 30322

Austell, Georgia

Status

Address

Piedmont Healthcare Pulmonary and Critical Care Research

Austell, Georgia, 30106

University of Chicago Medical Center, Chicago, Illinois

Status

Address

University of Chicago Medical Center

Chicago, Illinois, 60637

Ascension Alexian Brothers, Elk Grove Village, Illinois

Status

Address

Ascension Alexian Brothers

Elk Grove Village, Illinois, 60007

Indiana University School of Medicine, Indianapolis, Indiana

Status

Address

Indiana University School of Medicine

Indianapolis, Indiana, 46202

Community Heart and Vascular Hospital, Indianapolis, Indiana

Status

Address

Community Heart and Vascular Hospital

Indianapolis, Indiana, 46256

St. Vincent Medical Group, Inc., Indianapolis, Indiana

Status

Address

St. Vincent Medical Group, Inc.

Indianapolis, Indiana, 46260

University of Iowa Hospitals and Clinics, Iowa City, Iowa

Status

Address

University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242

Kentuckiana Pulmonary Research Center, Louisville, Kentucky

Status

Address

Kentuckiana Pulmonary Research Center

Louisville, Kentucky, 40202

Ochsner Medical Center, New Orleans, Louisiana

Status

Address

Ochsner Medical Center

New Orleans, Louisiana, 70121

Chest Medicine Associates, South Portland, Maine

Status

Address

Chest Medicine Associates

South Portland, Maine, 04106

University of Maryland Medical Center, Baltimore, Maryland

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Address

University of Maryland Medical Center

Baltimore, Maryland, 21201

Tufts Medical Center, Boston, Massachusetts

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Address

Tufts Medical Center

Boston, Massachusetts, 02111

Massachusetts General Hospital, Boston, Massachusetts

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Address

Massachusetts General Hospital

Boston, Massachusetts, 02114

Boston University Medical Center, Boston, Massachusetts

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Address

Boston University Medical Center

Boston, Massachusetts, 02118

Spectrum Health Medical Group, Grand Rapids, Michigan

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Address

Spectrum Health Medical Group

Grand Rapids, Michigan, 49546

Washington University School of Medicine, Saint Louis, Missouri

Status

Address

Washington University School of Medicine

Saint Louis, Missouri, 63110

Nebraska Medical Center, Omaha, Nebraska

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Address

Nebraska Medical Center

Omaha, Nebraska, 68198

University of New Mexico, Albuquerque, New Mexico

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University of New Mexico

Albuquerque, New Mexico, 87131

Winthrop Hospital, Mineola, New York

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Address

Winthrop Hospital

Mineola, New York, 11501

NYU Langone Medical Center, New York, New York

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NYU Langone Medical Center

New York, New York, 10016

New York, New York

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Address

Weill-Cornell-New York Presbyterian Hospital

New York, New York, 10021

Mount Sinai School of Medicine, New York, New York

Status

Address

Mount Sinai School of Medicine

New York, New York, 10029

University of Rochester, Rochester, New York

Status

Address

University of Rochester

Rochester, New York, 14642

Duke University Medical Center, Durham, North Carolina

Status

Address

Duke University Medical Center

Durham, North Carolina, 27710

East Carolina University, Greenville, North Carolina

Status

Address

East Carolina University

Greenville, North Carolina, 27834

Cincinnati, Ohio

Status

Address

University of Cincinnati-Medical Science Building

Cincinnati, Ohio, 45267

Cleveland Clinic, Cleveland, Ohio

Status

Address

Cleveland Clinic

Cleveland, Ohio, 44195

Columbus, Ohio

Status

Address

The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210

Integris Baptist Medical Center, Oklahoma City, Oklahoma

Status

Address

Integris Baptist Medical Center

Oklahoma City, Oklahoma, 73112

Oregon Clinic-Pulmonary West, Portland, Oregon

Status

Address

Oregon Clinic-Pulmonary West

Portland, Oregon, 97225

Oregon Health & Science University, Portland, Oregon

Status

Address

Oregon Health & Science University

Portland, Oregon, 97239

University of Pennsylvania, Philadelphia, Pennsylvania

Status

Address

University of Pennsylvania

Philadelphia, Pennsylvania, 19104

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Status

Address

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107

Temple University, Philadelphia, Pennsylvania

Status

Address

Temple University

Philadelphia, Pennsylvania, 19140

Allegheny General Hospital, Pittsburgh, Pennsylvania

Status

Address

Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212

StatCare Pulmonary Consultants, Knoxville, Tennessee

Status

Address

StatCare Pulmonary Consultants

Knoxville, Tennessee, 37919

Ascension Texas Cardiovascular, Austin, Texas

Status

Address

Ascension Texas Cardiovascular

Austin, Texas, 78705

UT Southwestern Medical Center, Dallas, Texas

Status

Address

UT Southwestern Medical Center

Dallas, Texas, 75390

Memorial Hermann Hospital, Houston, Texas

Status

Address

Memorial Hermann Hospital

Houston, Texas, 77030

Houston, Texas

Status

Address

The Methodist Hospital Research Institute

Houston, Texas, 77030

Vermont Lung Center, Burlington, Vermont

Status

Address

Vermont Lung Center

Burlington, Vermont, 05446

University of Virginia Medical Center, Charlottesville, Virginia

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Address

University of Virginia Medical Center

Charlottesville, Virginia, 22908

Norfolk, Virginia

Status

Address

Sentara Cardiovascular Research Institute

Norfolk, Virginia, 23507

Roanoke, Virginia

Status

Address

Carilion Clinic Pulmonary and Sleep Medicine

Roanoke, Virginia, 24014

Milwaukee, Wisconsin

Status

Address

Medical College of Wisconsin/Froedtert Hospital

Milwaukee, Wisconsin, 53226

International Sites

Hospital Italiano, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina

Status

Address

Hospital Italiano

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1181ACH

Santa Fe, Santa Fe De La Vera Cruz, Argentina

Status

Address

Hospital PROVINCIAL "Dr. Jose Maria Cullen"

Santa Fe, Santa Fe De La Vera Cruz, 3000

Sanatorio Parque S.A., Rosario, Santa Fe, Argentina

Status

Address

Sanatorio Parque S.A.

Rosario, Santa Fe, S2000DSV

Sanatorio de la Trinidad Mitre, Buenos Aires, Argentina

Status

Address

Sanatorio de la Trinidad Mitre

Buenos Aires, ,

Cardiologia Palmero, Caba, Argentina

Status

Address

Cardiologia Palmero

Caba, , 1425

Hospital Britanico de Buenos Aires, Ciudad Autonoma Buenos Aires, Argentina

Status

Address

Hospital Britanico de Buenos Aires

Ciudad Autonoma Buenos Aires, , 1280

Fundacion Respirar, Ciudad Autonoma Buenos Aires, Argentina

Status

Address

Fundacion Respirar

Ciudad Autonoma Buenos Aires, , 1426

Fundacion Favaloro, Ciudad Autonoma Buenos Aires, Argentina

Status

Address

Fundacion Favaloro

Ciudad Autonoma Buenos Aires, , C1093AAS

Cordoba, Argentina

Status

Address

Hospital Privado Centro Medico de Cordoba S.A

Cordoba, , X5016KEH

Instituto de Cardiologia de Corrientes, Corrientes, Argentina

Status

Address

Instituto de Cardiologia de Corrientes

Corrientes, ,

Hospital Italiano de Cordoba, Córdoba, Argentina

Status

Address

Hospital Italiano de Cordoba

Córdoba, , X5004BAL

Instituto de Investigaciones Clinicas, Mar Del Plata, Argentina

Status

Address

Instituto de Investigaciones Clinicas

Mar Del Plata, ,

Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia

Status

Address

Royal Prince Alfred Hospital

Camperdown, New South Wales, 2050

St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia

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Address

St Vincent's Hospital Sydney

Darlinghurst, New South Wales, 2010

Macquarie University, Sydney, New South Wales, Australia

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Address

Macquarie University

Sydney, New South Wales, 2109

Westmead Hospital, Sydney, New South Wales, Australia

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Address

Westmead Hospital

Sydney, New South Wales, 2145

Nepean Hospital, Sydney, New South Wales, Australia

Status

Address

Nepean Hospital

Sydney, New South Wales, 2751

The Prince Charles Hospital, Chermside, Queensland, Australia

Status

Address

The Prince Charles Hospital

Chermside, Queensland, 4032

Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

Status

Address

Princess Alexandra Hospital

Woolloongabba, Queensland, 4102

Royal Hobart Hospital, Hobart, Tasmania, Australia

Status

Address

Royal Hobart Hospital

Hobart, Tasmania, 7000

St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

Status

Address

St Vincent's Hospital Melbourne

Fitzroy, Victoria, 3065

The Alfred Hospital, Melbourne, Victoria, Australia

Status

Address

The Alfred Hospital

Melbourne, Victoria, 3004

Fiona Stanley Hospital, Perth, Western Australia, Australia

Status

Address

Fiona Stanley Hospital

Perth, Western Australia, 6150

Medizinische Universität Innsbruck, Innsbruck, Austria

Status

Address

Medizinische Universität Innsbruck

Innsbruck, , A-6020

Linz, Austria

Status

Address

Ordensklinikum Linz GmbH - Elisabethinen, Fadingerstrasse 1

Linz, , 4020

Wien, Austria

Status

Address

AKH Wien, Innere Med. II, Kardiologie, Währingergürtel 18-20

Wien, , 1090

Bruxelles, Belgium

Status

Address

Cliniques Universitaires de Bruxelles Hopital Erasme

Bruxelles, , 1070

Leuven, Belgium

Status

Address

UZ Leuven, UZ Leuven Campus Gasthuisberg, Herestraat 49

Leuven, , 3000

Goiânia, Goias, Brazil

Status

Address

HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás

Goiânia, Goias, 74605-020

Belo Horizonte, MG, Brazil

Status

Address

Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa

Belo Horizonte, MG, 30441-070

Hospital Sao Lucas da PUC-RS, Porto Alegre, R.S, Brazil

Status

Address

Hospital Sao Lucas da PUC-RS

Porto Alegre, R.S, 90610-000

Porto Alegre, RS, Brazil

Status

Address

Irmandade da Santa Casa de Misericórdia de Porto Alegre

Porto Alegre, RS, 90035-074

Botucatu, Sao Paulo, Brazil

Status

Address

UNESP-Faculdade de Medicina da Universidade Estadual Paulista Campus Botucatu

Botucatu, Sao Paulo, 18618-687

Hospital Sao Paulo, Sao Paulo, SP, Brazil

Status

Address

Hospital Sao Paulo

Sao Paulo, SP, 04037-002

Instituto do Coracao, Sao Paulo, SP, Brazil

Status

Address

Instituto do Coracao

Sao Paulo, SP, 05403-000

Sofia, Bulgaria

Status

Address

MHAT - "National Heart Hospital" EAD, 65, Konyovitza Str.

Sofia, , 1309

MHAT "Sveta Anna" Sofia AD, Sofia, Bulgaria

Status

Address

MHAT "Sveta Anna" Sofia AD

Sofia, , 1750

Peter Lougheed Centre, Calgary, Alberta, Canada

Status

Address

Peter Lougheed Centre

Calgary, Alberta, T1Y 6J4

University of Alberta Hospital, Edmonton, Alberta, Canada

Status

Address

University of Alberta Hospital

Edmonton, Alberta, T6G 2B7

LHSC - Victoria Hospital, London, Ontario, Canada

Status

Address

LHSC - Victoria Hospital

London, Ontario, N6A 5W9

Toronto, Ontario, Canada

Status

Address

University Health Network-Toronto General Hospital

Toronto, Ontario, M5G 2N2

Montreal, Quebec, Canada

Status

Address

SMBD Jewish General Hospital d/b/a Jewish General Hospital

Montreal, Quebec, H3T1E2

Québec, Quebec, Canada

Status

Address

Institut Universitaire de Cardiologie et de Pneumologie de Quebec

Québec, Quebec,

Instiuto Nacional del Torax, Providencia, Santiago De Chile, Chile

Status

Address

Instiuto Nacional del Torax

Providencia, Santiago De Chile, 7500691

Beijing, Beijing, China

Status

Address

Beijing Shijitan Hospital, Capital Medical University

Beijing, Beijing, 100038

Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China

Status

Address

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, 510080

Changsha, Hunan, China

Status

Address

Xiangya Hospital Central South University

Changsha, Hunan, 410008

Shanghai Pulmonary Hospital, Shanghai, Shanghai, China

Status

Address

Shanghai Pulmonary Hospital

Shanghai, Shanghai, 200443

Beijing, China

Status

Address

Fuwai Hospital, Chinese Academy of Medical Sciences

Beijing, , 100037

Zagreb, Croatia

Status

Address

Clinical Hospital Dubrava Zagreb, Avenija G.Šuška 6

Zagreb, , 10000

Zagreb, Croatia

Status

Address

University Clinic for Pulmonary Diseases, Jordanovac 104

Zagreb, , 10000

Praha 2, Czechia

Status

Address

Vseobecna fakultni nemocnice v Praze, II. interni klinika kardiologie a angiologie VFN a 1. LF UK, U nemocnice 2

Praha 2, , 128 08

Copenhagen, Denmark

Status

Address

Copenhagen University Hospital (Rigshospitalet)

Copenhagen, , 2100

Århus Universitetshospital, Århus, Denmark

Status

Address

Århus Universitetshospital

Århus, , 8200

Strasbourg, Bas Rhin, France

Status

Address

CHU de Strasbourg - Nouvel Hôpital Civil, Ctre de competence Hypertension Arterielle Pulmona, 1 place de l Hopital

Strasbourg, Bas Rhin, 67091

Grenoble, Isere, France

Status

Address

CHU de Grenoble - Hôpital Albert Michallon, Clinique de Cardiologie, Boulevrad de la Chantourne

Grenoble, Isere, 38048

Saint-Étienne, Loire, France

Status

Address

CHU de Saint-Etienne - Hopital Nord, Service de Medecine vasculaire et therapeutique, 81 Avenue A. Raimond

Saint-Étienne, Loire, 42005

Vandoeuvre les Nancy, Meurthe Et Moselle, France

Status

Address

CHU Nancy - Hôpital de Brabois Adultes, Pneumologie- Oncologie Médicale, Rue du Morvan

Vandoeuvre les Nancy, Meurthe Et Moselle, 54511

Bron cedex, Rhone, France

Status

Address

CHU Lyon - Hôpital Cardio-Vasculaire et Pneumologique Louis Pradel, Service de Pneumologie, 59 Boulevard Pinel

Bron cedex, Rhone, 69677

CHU de Rouen - Hôpital Charles Nicolle, Rouen cedex, Seine Maritime, France

Status

Address

CHU de Rouen - Hôpital Charles Nicolle

Rouen cedex, Seine Maritime, 76031

Le Kremlin-Bicêtre, Val De Marne, France

Status

Address

Groupement Hospitalier Sud - Hôpital Bicêtre, Service de Pneumologie, 78 Avenue du General Leclerc

Le Kremlin-Bicêtre, Val De Marne, 94275

CHU Besançon - Hôpital Jean Minjoz, Besançon Cedex, France

Status

Address

CHU Besançon - Hôpital Jean Minjoz

Besançon Cedex, , 25030

Brest cedex 2, France

Status

Address

CHU de Brest - Hôpital de la Cavale Blanche

Brest cedex 2, , 29609

CHRU de Lille - Hopital Cardiologique, Lille Cedex, France

Status

Address

CHRU de Lille - Hopital Cardiologique

Lille Cedex, , 59037

Hôpital Nord - CHU Marseille, Marseille, France

Status

Address

Hôpital Nord - CHU Marseille

Marseille, , 13015

Heidelberg, Baden-Württemberg, Germany

Status

Address

Thoraxklinik-Heidelberg Zentrum für Pulmonale Hypertonie

Heidelberg, Baden-Württemberg, 69126

Universitätsmedizin Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany

Status

Address

Universitätsmedizin Greifswald

Greifswald, Mecklenburg-Vorpommern, 17475

Mainz, Rheinland Pfalz, Germany

Status

Address

Universitaetsmedizin der Johannes-Gutenberg-Universitaet Mainz, Zentrum für Kardiologie I, Centrum für Thrombose und Hämostase (CTH), Langenbeckstrasse 1

Mainz, Rheinland Pfalz, 55131

Homburg, Saarland, Germany

Status

Address

Universitaetsklinikum des Saarlandes, Innere Medizin V, IMED, Kirrberger Strasse 100, Gebäude 41

Homburg, Saarland, 66424

Leipzig, Sachsen, Germany

Status

Address

Universitätsklinikum Leipzig, Medizinische Klinik II, Pneumologie

Leipzig, Sachsen, 04103

Schwarzwald-Baar Klinikum, Donaueschingen, Germany

Status

Address

Schwarzwald-Baar Klinikum

Donaueschingen, , 78166

Dresden, Germany

Status

Address

Universitaetsklinikum Carl Gustav Carus TU Dresden

Dresden, , 01307

Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany

Status

Address

Universitaetsklinikum Hamburg-Eppendorf

Hamburg, , 20246

Alexandroupolis, Greece

Status

Address

University General Hospital of Alexandroupolis

Alexandroupolis, , 68100

Athens, Greece

Status

Address

"Onasseio" Cardiosurgery Hospital, Hemodynamic Research and Interventional Cardiology Dept., 356, Syggrou Avenue

Athens, , 17674

University General Hospital Attikon, Chaidari, Greece

Status

Address

University General Hospital Attikon

Chaidari, , 12462

Thessaloniki, Greece

Status

Address

AHEPA General Hospital of Thessaloniki, A' Cardiology Clinic, 1 St. Kyriakidi Street

Thessaloniki, , 54636

Budapest, Hungary

Status

Address

Gottsegen György Országos Kardiovaszkuláris Intézet

Budapest, , 1096

Pecs, Hungary

Status

Address

Pecsi Tudomanyegyetem, Szivgyogyaszati Klinika, Ifjusag u. 13.

Pecs, , 7624

Haifa, Israel

Status

Address

The Lady Davis Carmel Medical Center, 7 Michal st.

Haifa, , 3436212

Jerusalem, Israel

Status

Address

Hadassah Ein Kerem Medical Center, Kiryat Hadassah

Jerusalem, , 9112001

Kfar- Sava, Israel

Status

Address

Meir Medical Center, 59 Tshernichovski st.

Kfar- Sava, , 4428164

Petach Tikva, Israel

Status

Address

Rabin Medical Center-Beilinson Campus, Pulmonary Institute, 39 Jabotinsky St Ground floor

Petach Tikva, , 4941492

Tel Aviv, Israel

Status

Address

Tel Aviv Sourasky Medical Center, 6 Weizmann St.

Tel Aviv, , 6423906

Palermo, PA, Italy

Status

Address

Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT)

Palermo, PA, 90127

Foggia, Italy

Status

Address

Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia, S.C. di Cardiologia, Viale Luigi Pinto, 1

Foggia, , 71100

IRCC Ospedale Policlinico San Martino, Genova, Italy

Status

Address

IRCC Ospedale Policlinico San Martino

Genova, , 16132

Milano, Italy

Status

Address

Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35

Milano, , 20122

Milan, Italy

Status

Address

Centro Cardiologico Monzino, IRCCS U.O. Scompenso

Milan, , 20138

Monza, Italy

Status

Address

Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo)

Monza, , 20900

Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

Status

Address

Fondazione IRCCS Policlinico San Matteo

Pavia, , 27100

Roma, Italy

Status

Address

Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza, Viale del Policlinico, 155

Roma, , 00161

Samsung Medical Center, Seoul, Gangnam-gu, Korea, Republic of

Status

Address

Samsung Medical Center

Seoul, Gangnam-gu, 06351

Seoul National University Hospital, Seoul, Jongno-gu, Korea, Republic of

Status

Address

Seoul National University Hospital

Seoul, Jongno-gu, 03080

Incheon, Namdong-gu, Korea, Republic of

Status

Address

Gachon University Hospital Gil Medical Center

Incheon, Namdong-gu, 21565

Mexico, Distrito Federal, Mexico

Status

Address

Instituto Nacional de Cardiologia Dr Ignacio Chavez Rivera

Mexico, Distrito Federal, 14080

Mexico, Distrito Federal, Mexico

Status

Address

Instituto Nacional de Ciencias Médicas y Nutricion Dr. Salvador Zubiran

Mexico, Distrito Federal, 14080

CICUM San Miguel, Guadalajara, Jalisco, Mexico

Status

Address

CICUM San Miguel

Guadalajara, Jalisco, 44160

Monterrey, N.l., Mexico

Status

Address

Unidad de Investigacion Clinica en Medicina, S.C.

Monterrey, N.l., 64718

VU Medisch Centrum, De Boelelaan 1117, Amsterdam, Netherlands

Status

Address

VU Medisch Centrum, De Boelelaan 1117

Amsterdam, , 1081 HV

Bialystok, Poland

Status

Address

Uniwersytecki Szpital Kliniczny w Bialymstoku, Klinika Kardiologii z Oddzialem Intensywnego Nazdoru Kardiologicznego, M. Sklodowskiej 24a

Bialystok, , 15-276

Krakow, Poland

Status

Address

Krakowski Szpital Specjalistyczny im. Jana Pawla II, Oddział Kliniczny Chorób Serca i Naczyń z Pododdziałem Intensywnego Nadzoru Kardiologicznego, Pradnicka 80

Krakow, , 31-202

Otwock, Poland

Status

Address

NZOZ Europejskie Centrum Zdrowia, ul. Borowa 14/18

Otwock, , 05-400

Poznan, Poland

Status

Address

Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu, Oddzial Kardiologii - F, ul. Dluga 1/2

Poznan, , 61-848

Premium Clinic Wrocław CM, Podwale 83/17, Wroclaw, Poland

Status

Address

Premium Clinic Wrocław CM, Podwale 83/17

Wroclaw, , 50-414

Hospital Garcia de Orta, E.P.E, Almada, Portugal

Status

Address

Hospital Garcia de Orta, E.P.E

Almada, , 2805-267

Coimbra, Portugal

Status

Address

Centro Hospitalar e Universitário de Coimbra, E.P.E.

Coimbra, , 3000-075

Lisboa, Portugal

Status

Address

Centro Hospitalar Universitário Lisboa Norte, E.P.E. Hospital Pulido Valente

Lisboa, , 1769-001

Porto, Portugal

Status

Address

Centro Hospitalar de Santo António, E.P.E.

Porto, , 4099-001

Bucharest, Romania

Status

Address

Institutul de Urgenta pentru Boli Cardiovasculare "Prof. Dr. C.C. Iliescu", Sos. Fundeni nr. 258

Bucharest, , 022328

Bucuresti, Romania

Status

Address

Institutul de Pneumoftiziologie "Marius Nasta", Sos. Viilor nr. 90, Sector 5

Bucuresti, , 050159

Cluj-Napoca, Romania

Status

Address

Institutul Inimii "Niculae Stancioiu" Cluj-Napoca, Cardiologie, Str. Motilor nr. 19-21

Cluj-Napoca, , 400001

Timisoara, Romania

Status

Address

Spitalul Clinic de Boli Infectioase si Pneumoftiziologie "Dr. Victor Babes" Timisoara, Str. Gheorghe Adam nr. 13

Timisoara, , 300310

Belgrade, Serbia

Status

Address

Clinical Center of Serbia, Koste Todorovica 8

Belgrade, , 11000

Belgrade, Serbia

Status

Address

Clinical Center Zemun. Clinic for internal medicine, Department of Cardiology

Belgrade, , 11080

Sremska Kamenica, Serbia

Status

Address

Institute for Pulmonary Diseases of Vojvodina, Put Dr Goldmana 4

Sremska Kamenica, , 21204

National University Hospital, Singapore, Singapore

Status

Address

National University Hospital

Singapore, , 119074

National Heart Centre, Singapore, Singapore

Status

Address

National Heart Centre

Singapore, , 169609

Barcelona, Spain

Status

Address

Hospital Universitari Vall d'Hebron, Respiratory Dept., Passeig Vall d'Hebron,119-129, Neumologia

Barcelona, , 08035

Barcelona, Spain

Status

Address

Hospital Clinic de Barcelona, C/ Villarroel, 170

Barcelona, , 08036

Hospital Universitario 12 de Octubre, Madrid, Spain

Status

Address

Hospital Universitario 12 de Octubre

Madrid, , 28041

Hospital Universitari i Politecnic La Fe, Valencia, Spain

Status

Address

Hospital Universitari i Politecnic La Fe

Valencia, , 46026

Sahlgrenska Universitetssjukhuset, Göteborg, Sweden

Status

Address

Sahlgrenska Universitetssjukhuset

Göteborg, , 41345

Linköping Universitetssjukhuset, Linköping, Sweden

Status

Address

Linköping Universitetssjukhuset

Linköping, , 58185

Umeå, Sweden

Status

Address

Norrlands Universitetssjukhus, Hjärtcentrum

Umeå, , 90185

National Cheng Kung University Hospital, Tainan, Taiwan

Status

Address

National Cheng Kung University Hospital

Tainan, , 704

National Taiwan University Hospital, Taipei, Taiwan

Status

Address

National Taiwan University Hospital

Taipei, , 10002

Osmangazi Uni Medical Faculty, Eskişehir, Odumpazari, Turkey

Status

Address

Osmangazi Uni Medical Faculty

Eskişehir, Odumpazari, 26480

Adana, Saricam, Turkey

Status

Address

Balcalı, Çukurova Üniversitesi Kardiyoloji ABD

Adana, Saricam, 01330

Mersin, Yenisehir, Turkey

Status

Address

Mersin Üniversitesi Tip Fakültesi Ciftlikköy Kampüsü

Mersin, Yenisehir, 33343

Gazi University Medical Faculty Hospital, Ankara, Turkey

Status

Address

Gazi University Medical Faculty Hospital

Ankara, , 06560

Bursa, Turkey

Status

Address

Uludag Universitesi Tip Fakültesi, Gorukle Kampusu

Bursa, , 16059

Istanbul, Turkey

Status

Address

Marmara Universitesi Istanbul Pendik Egitim ve Arastirma Hastanesi, Fevzi Cakmak Mahallesi Muhsin Yazicioglu Cad. No: 10

Istanbul, , 34899

Izmir, Turkey

Status

Address

Dokuz Eylul Universitesi Tip Fakultesi, Mithatpasa caddesi Inciralti Balcova

Izmir, , 35340

Dnipro, Ukraine

Status

Address

CE Dniprop RCC&C Center of Dniprop RC Dept of Card SI DMA of MOHU, Chair of Internal Medicine 3, 28, Knyazya Volodymyra Velykogo St.

Dnipro, , 49070

Kyiv, Ukraine

Status

Address

SI F.H.Yanovskyi National Institute of Phthisiology and Pulmonology of NAMSU, Clinical and Functional Dept, 10, Amosova St.

Kyiv, , 03680

Lviv, Ukraine

Status

Address

Communal Noncommercial Enterprise of Lviv Regional Council Lviv Clinical Hospital, Dept of Cardiology, D.Halytskyi Lviv NMU, Ch of Internal Medicine #1, 7, Chernihivska str.

Lviv, , 79010

London, Greater London, United Kingdom

Status

Address

Royal Free London NHS Foundation Trust, Pond Street

London, Greater London, NW3 2QG

Royal Brompton Hospital, London, Greater London, United Kingdom

Status

Address

Royal Brompton Hospital

London, Greater London, SW3 6NP

Newcastle upon Tyne, Tyne & Wear, United Kingdom

Status

Address

The Newcastle upon Tyne Hospitals NHS Foundation Trust, Sir William Leech Lung Research Centre, Freeman Hospital

Newcastle upon Tyne, Tyne & Wear, NE7 7DN

Golden Jubilee National Hospital, Glasgow, West Dunbartonshire, United Kingdom

Status

Address

Golden Jubilee National Hospital

Glasgow, West Dunbartonshire, G81 4DY

Hammersmith Hospital, London, United Kingdom

Status

Address

Hammersmith Hospital

London, , W12 0HS

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