This study aims to investigate the exercise profile in pulmonary hypertension patients with
either pulmonary arterial hypertension, chronic thromboembolic pulmonary hypertension or
pulmonary hypertension due to left heart disease and in disease control.
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The disease, disorder, syndrome, illness, or injury that is being studied.
This is a dual-center observational prospective study in patients with pulmonary arterial
hypertension, chronic thromboembolic pulmonary hypertension, pulmonary hypertension due to
left heart disease. Patients undergoing right heart catheterisation due to dyspnoe with
invasive exclusion of pulmonary hypertension will be recruited as disease control.
The study comprises a 1-day screening period, followed by a right heart catheterization with
The study starts with screening, information of the patients and Informed Consent Form
signature at day -1. Screening and inclusion of the patient can be performed on the same day.
On the day of the planned right heart catheterization based on clinical grounds, exercise
right heart catheterisation (RHC) using Swan-Ganz and/or Conductance catheters with
simultaneous echocardiography will be performed. End of study is defined as a complete
exercise RHC. Adverse events will be assessed until 1 day after the exercise RHC.
After placement of the Swan-ganz or Conductance catheter patients will undergo an exercise
challenge using the following protocol in semi-supine position until exhaustion:
: Pulmonary arterial hypertension
Patients with mean pulmonary arterial pressure above 25 mmHg, and a pulmonary capillary wedge pressure below 15 mmHg classified into group 1 of the clinical classification of pulmonary hypertension.
: Pulmonary hypertension due to left heart disease
Patients with mean pulmonary arterial pressure above 25 mmHg, and a pulmonary capillary wedge pressure above 15 mmHg with left heart disease, classified into group 2 of the clinical classification of pulmonary hypertension.
: Chronic thromboembolic pulmonary hypertension
Patients with mean pulmonary arterial pressure above 25 mmHg, and a pulmonary capillary wedge pressure below 15 mmHg with a history of pulmonary embolism, classified into group 4 of the clinical classification of pulmonary hypertension.
Patients with mean pulmonary arterial pressure below 25 mmHg, and a pulmonary capillary wedge pressure below 15 mmHg with exclusion of pulmonary hypertension.
Other: - Exercise
After placement of the right heart catheter patients will undergo an exercise challenge in semi-supine position until exhaustion
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Bad Nauheim, Hesse,
Richter J Manuel, MD
University of Giessen
Gießen, Hesse, 35390
Manuel Richter, MD