The purpose of this randomized, placebo-controlled double-blind trial is to evaluate the
effect of acetazolamide on right heart function at rest in lowlanders with chronic
obstructive pulmonary disease (COPD) traveling to high altitude (HA) and developing early
signs of altitude-illness.
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.
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This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.
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Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.
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The disease, disorder, syndrome, illness, or injury that is being studied.
This randomized placebo-controlled, double-blind, parallel-design trial will evaluate effect
of acetazolamide on right heart function in lowlanders with chronic obstructive pulmonary
disease (COPD) travelling to high altitude and developping early symptoms and/or signs of
impending altitude-illness. Qualifying participants will be randomized 1:1 to acetazolamide
or placebo treatment during their further stay of 2 days at 3'100 m.
Acetazolamide (oral capsules @125 mg), starting dose 3 capsules (375 mg), subsequent doses 1 capsule (125 mg) in the morning, 2 capsules (250 mg) in the evening, administered in qualifying participants, during the stay at 3100 m.
Placebo Comparator: Placebo
Placebo (oral capsules, identically looking as active drug), starting dose 3 capsules, subsequent doses
1 capsule in the morning, 2 capsules in the evening, administered in qualifying participants, during the stay at 3100 m.
Drug: - Acetazolamide
Drug: - Placebo
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
National Center of Cardiology and Internal Medicine
Bishkek, , 720040
Talant M Sooronbaev, MD