Physical Activity, Air Pollution, and High Blood Pressure

Study Purpose

The investigators are investigating the effects of traffic-related air pollution (TRAP) on the cardiovascular and pulmonary response to exercise in patients with hypertension using a real world randomized, crossover study design. Participants will be exposed to 2 conditions: a low TRAP environment and a high TRAP environment. Each exposure will consist of 30 min of moderate-intensity exercise. Cardiovascular and pulmonary health outcomes will be measured before, during, and up to 24 hours following exposures. A minimum washout period of 1 week will be used to minimize carryover effects.

Recruitment Criteria

Accepts Healthy Volunteers Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms	No
Study Type An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies.	Interventional
Eligible Ages	40 Years - 70 Years
Gender	All

More Inclusion & Exclusion Criteria

Inclusion Criteria:

1. Age between 40-70 years of age. 2. Previously diagnosed with elevated blood pressure or hypertension by a physician.

Exclusion Criteria:

1. Current or ex-smokers (abstinent for less than one year) 2. Lives with an individual who currently smokes cigarettes, e-cigarettes (i.e., vaping), or cannabis. 3. Hormone replacement therapy use. 4. Currently on beta-blocker or angiotensin receptor blocker (ARB) therapy. 5. Currently using over the counter drugs or supplements that may alter cardiovascular measures (as per the principal investigator's discretion) 6. Prior diagnosis of any other existing cardiovascular or pulmonary diseases and/or conditions (other than hypertension) 7. Musculoskeletal injury or lower limb limitation preventing safe engagement in moderate-intensity exercise

Trial Details

Trial ID: This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.	NCT05092672
Phase Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.	N/A
Lead Sponsor The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.	University of British Columbia
Principal Investigator The person who is responsible for the scientific and technical direction of the entire clinical study.	Michael Koehle, MD, PhD
Principal Investigator Affiliation	Professor
Agency Class Category of organization(s) involved as sponsor (and collaborator) supporting the trial.	Other
Overall Status	Recruiting
Countries	Canada
Conditions The disease, disorder, syndrome, illness, or injury that is being studied.	Essential Hypertension

Arms & Interventions

Arms

Experimental: High traffic-related air pollution first

Participants will exercise in an environment with high levels of traffic-related air pollution first. Afterwards, participants will complete the same exercise in an environment with low levels of traffic-related air pollution.

Experimental: Low traffic-related air pollution

Participants will exercise in an environment with low levels of traffic-related air pollution first. Afterwards, participants will complete the same exercise in an environment with high levels of traffic-related air pollution.

Interventions

Behavioral: - Exercise

Participants will engage in moderate-intensity (40-59% HRR) exercise for 30 min

Contact a Trial Team

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