Due to radiation exposure and low but real risk of morbidity and mortality associated with
right heart catheterization, non-invasive procedures to estimate mPAP are desired for the
diagnosis of PH or to monitor treatment effectiveness. Echocardiography is used as a
screening tool to estimate systolic pulmonary arterial pressure (sPAP), but due various
limitations, this technique is not considered to be sufficiently accurate for the diagnosis
of PH. The aim of 4D flow MRI is to evaluate the complete time-varying tridirectional
velocity field in a volume of interest. It enables flow and velocity measurements in a
vascular region of interest and visualization of vector plots of blood flow velocity fields.
Previous studies have shown on the one hand, correlations between mPAP and hemodynamic
parameters obtained by phase contrast MRI and, on the other hand, appearance of a vortical
blood flow in the pulmonary artery in PH. More studies are required to confirm 4D MRI as a
valuable tool for mPAP estimation in PH.
Following screening echocardiography, all patients will undergo right heart catheterization
for PH assessment. Then, all patients will be referred for a complete cardiac MRI exam with
the addition of a 4D Flow sequence (does not require supplementary injection of a contrast
agent and does not extend the duration of the examination) followed promptly (within the same
hour) by a Doppler-echocardiography. The data from each examination will be blindly
interpreted from the results of the other one. No follow-up will be required for the study.
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms
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