In this prospective study, the investigators will implement a systematic assessment of
adherence to diuretics in a cohort of patients with precapillary pulmonary hypertension.
This study is designed to:
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.
An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.
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This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.
Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.
Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.
Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.
The person who is responsible for the scientific and technical direction of the entire clinical study.
Category of organization(s) involved as sponsor (and collaborator) supporting the trial.
The disease, disorder, syndrome, illness, or injury that is being studied.
Introduction Precapillary pulmonary hypertension (PH) is characterized by remodeling of small
pulmonary arteries leading to a progressive increase in pulmonary vascular resistance (PVR)
resulting to right heart failure and ultimately death. The prognosis of PH is closely related
to the ability of the right ventricle to adapt to the progressive increase in PVR. The
occurrence of acute right ventricular decompensation is associated with a very poor prognosis
at short term.
The management of precapillary PH is based on specific therapies combined with general
measures and supportive therapies. Diuretic treatment is recommended in PAH patients with
signs of RV failure and fluid retention (recommendation class I, level of evidence C). The
beneficial effect of diuretics is probably essential for preventing episodes of acute right
ventricular decompensation. However, no study analyzed the rate of adherence to diuretic
regimen in PH patients and the impact of patterns of adherence to diuretics on the outcomes
Aim and objectives. The main objectives of this study are to:
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Hospital Bicêtre - Pneumology department
Le Kremlin-Bicêtre, , 94275
Marie-Camille Chaumais, PharmD, PhD