The investigators intend to evalute the value of radiomics signature of pulmonary vessels
from chest computed tomography (CT) for dianosis and prognosis of pulmonary arterial
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.
An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.
Searching Both is inclusive of interventional and observational studies.
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.
Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.
Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.
Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.
The person who is responsible for the scientific and technical direction of the entire clinical study.
Category of organization(s) involved as sponsor (and collaborator) supporting the trial.
The disease, disorder, syndrome, illness, or injury that is being studied.
Pulmonary arterial hypertension (PAH) is a heterogeneous disorder composed of varying
pathobiology that may involve multiple clinical conditions. Computed tomography (CT) is a
minimally invasive imaging technique capable of providing both high contrast and high
resolution detail of the lungs and arteries. Application of radiomics as prognosis and
diagnosis tools could quantifies high-dimensional features from CT data to investigate
vescualr heterogeneity.Development and validation of PAH diagnosis Algorithms based on
radiomics may serve as a complementary readout to current CT-based metrics and provide
valuable evidence to make the treatment management decision in early PAH.
: The development cohort
The development cohort was composed of patients diagnosed with PAH and healthy control group from 2019.1-2021.5 in RenjiH.
: The validation cohort
The validation cohort was composed of patients are suspected as PAH by echocardiography in 2021.5-2021.12 or suspected patients are form other medical institutions.
Other: - calculated radscore
The development cohort is case_control research. The validation cohort is prospective study to test the accuracy of calculated radscore based on diagonisis model.
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Shanghai, , 200127
Binaqian Ruan, postgraduate