Consistency of Electrical Cardiometry and Pulmonary Artery Catheter

Study Purpose

Currently, the gold standard method to estimate CO in patients with PAH or RV dysfunction is pulmonary artery catheter (PAC), however, the invasiveness and complexity of PAC has limited its usefulness in many clinical scenarios. By measuring the thoracic electrical bioimpedance, electrical cardiometry (EC) technique has been reported to noninvasively estimate cardiac output (CO) and other parameters related to cardiac contractility and fluid status in various cardiovascular disorders. However, in patients with pulmonary arterial hypertension (PAH) and/or right ventricular (RV) dysfunction, few study has been reported. The aim of this study is to evaluate the agreement between CO measured by PAC as the referenced method and CO measured by EC technique in patients with PAH and/or RV dysfunction.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.

An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.

Searching Both is inclusive of interventional and observational studies.

Eligible Ages 18 Years - 80 Years
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - adult cardiac surgery patients.
  • - pulmonary artery hypertension and/or right heart dysfunction.
  • - mechanical ventilation.

Exclusion Criteria:

  • - life threatening arrhythmia.
  • - severe valve regurgitation.
- left ventricular ejection fraction less than 30% - patients with mechanical circulatory support

Trial Details

Trial ID:

This trial id was obtained from, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.


Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Shanghai Zhongshan Hospital
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Guang-wei Hao, PhD
Principal Investigator Affiliation Fudan University
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Overall Status Recruiting
Countries China

The disease, disorder, syndrome, illness, or injury that is being studied.

Pulmonary Arterial Hypertension, Right Ventricular Dysfunction
Arms & Interventions


Experimental: patients with pulmonary artery hypertension and/or right ventricular dysfunction


Behavioral: - passive leg raising

transfer a patient from semi-recumbent position to supine position with a 45° leg lifting

Drug: - dobutamine test

infusion dobutamine

Drug: - inhaled nitric oxide

nitric oxide inhalation

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International Sites

Zhongshan hospital Fudan University, Shanghai, Shanghai, China




Zhongshan hospital Fudan University

Shanghai, Shanghai, 200032

Site Contact

Guo-wei Tu, PhD

64041990 #2923

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