Comparison of Different Cardiac Output Measurement Methods in Patients Undergoing Right Heart Catheterization

Study Purpose

The objective of this observational study is to compare cardiac output evaluation by the Direct Fick method, Indirect Fick method and Thermodiluition in pulmonary hypertension (PH) patients undergoing right heart catheterization (RHC). The main questions it aims to answer are:

  • - Are these methods interchangeable? - Can possible discrepancies influence risk stratification and therapeutic management of PH patients? All consecutive patients aged ≥18 years, referred for RHC for suspected PH, will be included.
Exclusion criteria will be contraindications to RHC, cardiac shunts and failure to obtain informed consent. Patients will undergo RHC by a Swan-Ganz catheter through the right internal jugular vein ultrasound-guided cannulation and cardiac output will be calculated using the three above-mentioned methods.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.

An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.

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Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - Age ≥18 years.
  • - Suspected pulmonary hypertension at clinical and echocardiographic evaluation.

Exclusion Criteria:

  • - contraindication to Right Heart Catheterization (RHC) - cardiac shunt.
- inability to provide informed consent

Trial Details

Trial ID:

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Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

UOSD Emodinamica Diagnostica e Interventistica
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Livio Giuliani, MD PhD
Principal Investigator Affiliation Interventional Cardiology Unit, SS Annunziata Hospital, Chieti
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Overall Status Recruiting
Countries Italy

The disease, disorder, syndrome, illness, or injury that is being studied.

Pulmonary Hypertension
Arms & Interventions


: patients undergoing right heart catheterization


Diagnostic Test: - right heart catheterization

Right heart catheterization (RHC) is an invasive hemodynamic procedure that allows direct measurement of right-sided cardiac pressures, calculation of cardiac output and pulmonary vascular resistance. It is the gold standard for the diagnosis of pulmonary arterial hypertension. Right heart catheterization is commonly performed by accessing the internal jugular vein (echo-guided access). Swan Ganz catheter with a dedicated thermistor is used to perform RHC; it is advanced through the right heart chambers to measure right atrial, right ventricle, pulmonary artery and pulmonary arterial wedge pressures. Cardiac output is measured using Fick direct, Fick indirect and thermodilution methods.

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International Sites

Chieti, Italy




UOSD Emodinamica Diagnostica e Interventistica Ospedale SS Annunziata

Chieti, , 66100

Site Contact

Livio Giuliani, MD PhD


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