Circulating MrgD in Pulmonary Hypertension

Study Purpose

The aim of the study is to observe the change of the circulating MrgD level in patients with pulmonary hypertension compared with subjects without pulmonary hypertension.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.

An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.

Searching Both is inclusive of interventional and observational studies.

Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion criteria for patients with pulmonary hypertension: 1. Male or female aged ≥18 years. 2. Right heart catheterisation to check the mean pulmonary artery pressure (mPAP) ≥25mmHg. 3. The patient is willing and able to provide written informed consent. Exclusion criteria for patients with pulmonary hypertension: 1. Age less than 18 years old. 2. Mean pulmonary artery pressure (mPAP) <25mmHg. 3. Unable to provide informed written consent for participation in the study. 4. Renal insufficiency. 5. Liver insufficiency. 6. Malignant tumor. 7. Active infection. 8. Pregnancy. Inclusion criteria for control subjects: 1. Male or female aged ≥18 years. 2. No evidence of pulmonary hypertension on echocardiography or mean pulmonary artery pressure (mPAP) < 25 mmHg on right heart catheterization, and no evidence of clinically relevant heart disease. 3. No evidence of clinically relevant pulmonary disease. Exclusion criteria for control subjects: 1. Age less than 18 years old. 2. Mean pulmonary artery pressure (mPAP) ≥25mmHg. 3. Unable to provide informed written consent for participation in the study. 4. Symptoms of heart failure or clinically relevant lung disease. 5. Renal insufficiency. 6. Liver insufficiency. 7. Malignant tumor. 8. Active infection. 9. Pregnancy

Trial Details

Trial ID:

This trial id was obtained from, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.


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Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Qilu Hospital of Shandong University
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Principal Investigator Affiliation N/A
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Overall Status Recruiting
Countries China

The disease, disorder, syndrome, illness, or injury that is being studied.

Pulmonary Hypertension
Arms & Interventions



: Non-PAH


Diagnostic Test: - Western blot

Samples were measured by Western blot using a solution for the separation of lymphocytes from peripheral blood.

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International Sites

Qilu Hospital of Shandong University, Jinan, Shandong, China




Qilu Hospital of Shandong University

Jinan, Shandong, 250012

Site Contact

Panpan Hao, MD, PHD


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