This is a FIH, double-blind, placebo-controlled, within-group randomised, trial designed to
evaluate the safety, tolerability, and pharmacokinetics (PK) of single and multiple ascending
oral doses of compound 106 (C106) in healthy females of non-childbearing potential and
The trial will be conducted in 2 parts:
Part A, single ascending dose (SAD) including a food interaction cohort: safety,
tolerability, and PK in healthy males and healthy females of non-childbearing potential
receiving single ascending doses of C106.
Part B, multiple ascending dose (MAD): safety, tolerability, and PK in healthy males...
Pulmonary arterial hypertension (PAH) in patients with congenital heart disease (CHD) is
associated with considerable morbidity and even mortality.
Next to environmental risk factors, the investigators believe that there is an important role
of genetic predisposition to develop PAH in CHD. There often is a discrepancy between the
severity of PAH and the CHD, where it is useful to screen for PAH gene mutations. The
investigators hypothesize that the genotype is partly responsible for the phenotypic
variability in patients with congenital shunt lesions, where some develop PAH and others do
not. If a genetic predisposition for PAH in...
The investigators are performing this research study to determine whether having low
iron-sulfur cluster levels can cause a disease known as pulmonary hypertension (PH). PH is
defined as abnormally high blood pressure in the arteries of the lungs.
Usually, small specialized structures inside each human cell called mitochondria are in
charge of generating energy within lung arteries for normal function. During situations of
disease or stress, lung arteries undergo a change in the function of mitochondria, resulting
in the development of PH. In studies on mice, investigators have learned that alterations in
the production of specific...
The aim of this study is to investigate the frequency and implications of pulmonary
hypertension in lung cancer patients. To do so, data will be collected from all lung cancer
patients at the university hospital Giessen. All data will be analyzed for possible hints of
pulmonary hypertension as a comorbidity in lung cancer patients. All information will be
generated from the regular guidelines based course of treatment and there will be no
interventions. This study will serve as a prospective register for all lung cancer patients
treated at the university hospital Giessen.
Giessen Pulmonary Hypertension Registry and Biobank
Pediatric idiopathic pulmonary hypertension has significant morbidity and mortality. An ever
expanding body of knowledge indicates the important contribution of inflammation to
pathogenesis and successful treatment with glucocorticoids. Over the last several years the
investigators have utilized steroids in patients with severe pulmonary hypertension as part
of a treatment regimen. These basic science studies possibly identifies a biochemical
etiology for the development of disease and may also be impacted by the administration of
steroids. Additionally, there is a commercially available assay which tests for all of the
The CADRE study is a multinational observational cohort of patients with sickle-cell disease
(SCD) in five west and central sub-Saharan African countries. The aim of this project is to
describe the incidence and assess the predictive factors of SCD-related micro- and
macro-vascular complications in sub-Saharan Africa.
A heart catheterization is a diagnostic heart procedure used to measure pressures and take
pictures of the blood flow through the heart chambers. Magnetic resonance imaging (MRI)
fluoroscopy shows continuous pictures of the heart chambers that doctors can watch while they
work. Researchers want to test this procedure with catheterization tools routinely used in
x-ray catheterization called guidewires. Guidewires will help move the heart catheter through
the different heart chambers. Guidewires are usually considered unsafe during MRI because MRI
can cause a guidewire to heat while inside the blood vessels and heart....
To study hemodynamic effects of Sildenafil during exercise in patients with pulmonary
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by obstruction of the
pulmonary vasculature by residual organized thrombi, leading to increased pulmonary vascular
resistance (PVR), progressive pulmonary hypertension, and right heart failure.
Medical therapy and balloon angioplasty (BPA) are effective treatment alternatives in
lowering pulmonary pressures and increasing pulmonary flow.
The aim of this study is to assess the hemodynamic effects of BPA or medical therapy on the
pressure-flow relationship in the pulmonary vasculature and the pulmonary vascular