The purposes of this study are (I), to evaluate various screening methods for their ability
to predict and to confirm Pulmonary Hypertension (PH) in scleroderma patients, and (II) to
evaluate the incidence of PH (i.e. the number of new cases per year) in scleroderma patients.
The purpose of this randomized, placebo-controlled double-blind trial is to evaluate the
effect of acetazolamide on right heart function at rest in lowlanders with chronic
obstructive pulmonary disease (COPD) traveling to high altitude (HA) and developing early
signs of altitude-illness.
The purpose of this study is to evaluate the effect of a parenteral emulsion containing n-3
long-chain polyunsaturated fatty acids (LC-PUFA) in fish oil on clinical outcomes, markers of
inflammation and oxidative stress, and pain in neonates with persistent pulmonary
hypertension of the newborn (PPHN) compared with those who receive an emulsion containing soy
oil and medium-chain triglycerides (MCT) without n-3 LC-PUFA.
This is a Phase 2, parallel group study to evaluate the safety, tolerability, PK, and
exploratory efficacy of 3 doses of CS1 in the treatment of PAH using the CardioMEMS HF System
to obtain repeated measurements of PAP and other hemodynamic parameters.
Elegible subjects will have a RHC to implant the CardioMEMS pulmonary artery (PA) Sensor
followed by a Baseline Period for the subject to become familiar with the system, its
measurements, how to send the data, and establish Baseline PA pressure. Alternately, the
subject may already have the CardioMEMS HF System and is willing to have the system
recalibrated in conjunction with RHC....
Chronic pulmonary hypertension (PH) is associated with impaired exercise capacity, quality of
life and right ventricular function.The disease is characterized by an increase of pulmonary
vascular resistance and pulmonary arterial pressure, leading to right heart insufficiency. In
later stages of the disease, the right heart is not able to further increase right
ventricular contractility (cardiac index) during exercise. Within the last decade, new
disease-targeted medical therapies have been approved for treatment of pulmonary arterial
hypertension (PAH). Sequential and upfront combinations of these agents have shown to further
Pulmonary Hypertension (PH) is a serious disease with a dismal prognosis when left untreated.
Advances in medical therapy have improved survival according to recent registries and
systematic reviews, but are associated with high healthcare costs.
Earlier studies in Heidelberg, Germany showed good evidence for the effect of exercise
training on improving exercise performance, quality of life and pulmonary hemodynamics in
patients with pulmonary hypertension.
The main objectives of the present project are:
1. to investigate the quality of the implementation of a standardized 3 week in-hospital
Hypotension during anesthesia often occurs because reduced systemic vascular resistance and
blocked sympathetic nervous system by anesthetic drugs. In patients who are taking
hypertension medication, blood pressure drops are exaggerated by inadequate compensation
mechanism due to decrease of blood vessel elasticity and desensitization of baroreceptors. In
one-lung ventilation (OLV) during thoracic surgery, persistent perfusion of non-ventilatory
lungs can lead to increased intra-pulmonary shunt and hypoxemia. As a compensatory mechanism,
the gravitational effect and hypoxic pulmonary vasoconstriction occur. Among these, hypoxic
The goal of this crossover trial is to determine whether the study drug
dehydroepiandrosterone (DHEA) improves right ventricular longitudinal strain measured by
cardiac magnetic resonance imaging at 18 weeks compared to placebo and to assess side effects
and safety in pulmonary arterial hypertension.
Although there has been some progress in pharmacological management of PAH, limited
functional capacity and low survival still persist, but there is evidence that exercise
training can be accomplished without adverse effects or damage to cardiac function and
pulmonary hemodynamics. Specifically, improvements in symptoms, exercise capacity, peripheral
muscle function and quality of life. Training programs need to be better studied and well
defined, and their physiological effects during physical training and functional capacity.
The aim of this study is to compare the effects of different training exercises on physical
To study the effect of acute normobaric hypoxia during exercise in patients with pulmonary
hypertension with/without Sildenafil