Systemic sclerosis (SSc, AKA scleroderma) is an autoimmune condition characterized by
endothelial damage and progressive fibrosis of the skin and internal organs. One of the
leading causes of morbidity and mortality in patients with SSc is pulmonary hypertension
(PH), which is estimated to occur in up to 31% of high risk SSc patients. Early detection of
patients with SSc-PH may lead to improved outcomes and although there have been concerted
efforts to accurately screen for SSc-PH, these patients continue to present with advanced
disease and suffer from poor survival. Therefore, better methods to screen for patients with
The primary objective is to evaluate the efficacy of continuous positive pressure on
resolution of high-altitude pulmonary edema vs high flow oxygen. The secondary objective is
to derive an incidence of high-altitude pulmonary edema based on the elevation and timing
from which the subject arrives. Additionally, in a convenience sample of the base study
population, an ultrasound evaluation for the presence of B lines in the lungs will be
conducted after 2 hours.
The six-minute walk test (6MWT) is a standard method for measuring exercise capacity in
patients with cardiopulmonary disease such as pulmonary hypertension (PAH) and measures how
far a patient can walk in 6 minutes. The test is usually performed in the hospital, by
walking along a hospital corridor. Since the outbreak of SARS-CoV-2, there has been a need to
minimise patient contact with hospitals and their staff to reduce transmission of the virus.
In a previous research project called 6APP, the investigators designed, developed and
evaluated a mobile phone app, to allow them to perform the 6MWT in the community. Given the
In Patients with rheumatic disease exercise training is a well established element of
therapy. In contrast patients with severe pulmonary hypertension are advised to avoid
physical exertion and must not perform exercise training. This study aims to evaluate the
effectivity and safety of a low-dose training program in patients with pulmonary hypertension
and rheumatic disease.
This study aims to investigate the exercise profile in pulmonary hypertension patients with
either pulmonary arterial hypertension, chronic thromboembolic pulmonary hypertension or
pulmonary hypertension due to left heart disease and in disease control.
In this study, the effects of kettlebell exercise training on functional capacity, dyspnea
and activities of daily living in patients diagnosed with Pulmonary Arterial Hypertension
(PAH) will be investigated.
This research study is being done to find out if exercise therapy can help improve the heart
function, overall health, and quality of life of patients with pulmonary hypertension caused
by heart failure.
Prospective, open-label, single centre, observational study to evaluate the safety and
feasibility of using pulmonary artery pressure (PAP) monitors and wearable activity monitors
in patients with pulmonary hypertension (PH).
Congenital diaphragmatic hernia (CDH) occurs when the diaphragm fails to fully fuse and
leaves a portal through which abdominal structures can migrate into the thorax. In the more
severe cases, the abdominal structures remain in the thoracic cavity and compromise the
development of the lungs. Infants born with this defect have a decreased capacity for gas
exchange; mortality rates after birth have been reported between 40-60%. Now that CDH can be
accurately diagnosed by mid-gestation, a number of strategies have been developed to repair
the hernia and promote lung tissue development.
Fetal tracheal occlusion (FETO), using a...
Tracheal occlusion IDE approved by FDA for congenital diaphragmatic hernia fetuses.