This trial will investigate whether patiens admitted with an acute exacerbation of chronic
obstructive lung disease and pulmonary hypertension will benefit from a targeted
This observational study aims to assess correlation of right atrial strain measured by
two-dimensional speckle tracking echocardiography with intraoperatively measured pulmonary
artery pressures, other indices of right ventricular function and short term postoperative
Pulmonary hypertension (PH) is defined as a pulmonary arterial mean pressure (meanPAP) ≥ 25
mmHg measured in the right heart catheterization.
There are different forms of PH defined in the classification of Dana Point 2008.
PH is diagnosed with right heart catheterization but there are other non invasive methods
which can be used for screening like the echocardiography, stress echocardiography and cardio
pulmonary exercise testing. In the diagnosis process and in the follow up of PH patients
biomarkers like NTproBNP are helpful. There are no specific biomarkers for the disease which
can make the diagnosis process easier and...
The BNP-PL is a multicenter, observational study in which patients are prospectively followed
in order to investigate clinical course and management of pulmonary hypertension in Poland.
All patients diagnosed with pulmonary arterial hypertension and chronic thromboembolic
pulmonary hypertension confirmed in right heart catheterization, will be eligible to
participate in the study.
In this study, hyperpolarized 129Xe MRI will be used to evaluate treatment efficacy in
patients with pulmonary arterial hypertension (PAH). Participants will be imaged at 4
timepoints (baseline, 6 weeks post-therapy initiation, 12 weeks, and 18 weeks). Images will
be analyzed to develop new biomarkers and to understand treatment effects.
The goal of this research is to optimize the MRI system to obtain ideal lung images using
Hyperpolarized (HP) Noble and Inert Fluorinated Gases as contrast agents. Lung coils tuned to
the frequencies of these gases will be used. This study will take place at TBRHSC in the
Cardiorespiratory Department and in the Research MRI facility.
Physiological cardiovascular stress test plays a crucial role in the assessment of patients
with suspected heart disease. There are several methods of cardiac physiological stress tests
and each of them offer varied insight into cardiac physiological adaptation: passive leg
raise, intra-venous fluid challenge, pharmacological stressors and physical exercise stress
test. Echocardiography, which is the mainstay for the non-invasive rest/stress assessment of
the left ventricular (LV) haemodynamics has several limitations. Novel methods of CMR imaging
allow to map intra-cardiac flow in three-dimension using novel flow acquisitions. These...
The aim of the study is to determine relevant morphologic parameters of the lung vasculature
for the differentiation between different groups of patients with pulmonary hypertension (PH)
by thoracic computer tomography (CT). In this pilot study patients undergoing right heart
catheterization will be investigated by thoracic CT and special software to determine
The investigators expect that using this non-invasive method, parameters relevant for the
differentiation of the patients with PH can be determined.
Pulmonary embolism, or clots blocking the blood vessels of the lungs, is a common clinical
condition requiring treatment with blood thinners. In most patients, recovery is complete. A
small proportion of patients, however, develop complications (high blood pressure in the lung
circulation, i.e. pulmonary hypertension). Persisting breathlessness during activity is a
common symptom in many of these patients and leads to a reduced ability to engage in daily
physical activity. The reason for this activity-related breathlessness remains uncertain and
is the main question of the proposed study. Using new sophisticated technology, the
The purposes of this study are (I), to evaluate various screening methods for their ability
to predict and to confirm Pulmonary Hypertension (PH) in scleroderma patients, and (II) to
evaluate the incidence of PH (i.e. the number of new cases per year) in scleroderma patients.